When prepared in water at 100 mg/mL, this material is expected to be clear to very slightly hazy in solution. While there is no specification for the color,
historical records indicate a range of faint yellow to light brown in solution.
H9523
Serotonin hydrochloride
Serotonin hydrochloride
1 of 2 reviewers received a sample product or took part in a promotion
≥98%, powder, neurotransmitter
Synonym(s):
3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
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Select a Size
25 MG
R 924,14
100 MG
R 2 799,86
250 MG
R 4 988,20
1 G
R 13 512,24
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25 MG
R 924,14
100 MG
R 2 799,86
250 MG
R 4 988,20
1 G
R 13 512,24
About This Item
Empirical Formula (Hill Notation):
C10H12N2O · HCl
CAS Number:
Molecular Weight:
212.68
Beilstein:
3570963
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
Serotonin hydrochloride, powder
Assay
≥98%
Quality Level
form
powder
color
white to off-white
mp
149-154 °C (lit.)
solubility
H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
InChI key
MDIGAZPGKJFIAH-UHFFFAOYSA-N
Gene Information
human ... HTR3A(3359)
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General description
Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen.[1] It is produced in the axon terminal present in the brain.[2] Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions.[2] It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition.[2] Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.[3]
Application
Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids[4], to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells[5], in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line[6]
Biochem/physiol Actions
Neurotransmitter.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Solutions should be freshly prepared.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Rhian Stavely et al.
Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)
Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious
Articles
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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Hello, what colour is the solution supposed to be when dissolved? Best, Anaïs
1 answer-
Helpful?
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Can it be stored -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
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What is the purity of Product H9523, Serotonin hydrochloride?
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This product must be at least 98% pure according to our specifications. The purity for individual lots can be found on the certificate of analysis.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Has Product H9523, Serotonin hydrochloride, been cell culture tested?
1 answer-
No. We do not test this product for cell culture suitability.
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What are the storage conditions for Product H9523, Serotonin hydrochloride?
1 answer-
This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.
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Can I store solutions of Product H9523, Serotonin hydrochloride?
1 answer-
Solutions of this product are unstable. We recommend preparing this solution fresh for each application.
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Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?
1 answer-
This product is the neurotransmitter serotonin. Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.
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