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Sigma-Aldrich

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid

average Mn 1,000 (n~22), cross-linking reagent amine reactive, cross-linking reagent thiol reactive

Synonym(s):

Polyethylene glycol, mercaptoPEG acid, mercaptopoly(ethylene glycol) carboxylic acid, mercaptopolyoxyethylene acetic acid, thio-PEG, thiol-PEG-acid, thiol-PEG-carboxylate

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About This Item

Linear Formula:
HSC2H4O(C2H4O)nCH2CO2H
CAS Number:
165729-81-7
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid, average Mn 1,000

form

solid

mol wt

PEG average Mn 1,000 (n~22)
average Mn 1,000

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive

transition temp

Tm 40-45 °C

Ω-end

thiol

α-end

carboxylic acid

polymer architecture

shape: linear
functionality: heterobifunctional

storage temp.

−20°C

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Application

  • bioconjugation
  • drug delivery
  • PEG hydrogel
  • crosslinker
  • surface functionalization
Reported applications include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

>604.4 °F

Flash Point(C)

> 318 °C

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S M Barber et al.
The journal of physical chemistry. A, 110(13), 4538-4542 (2006-03-31)
We have developed an efficient method for producing difunctional, bilateral nanospheres. A monolayer of nanoparticles was prepared followed by deposition of a thin layer of metal. By varying the base particle and metal deposited, bilateral nanoparticles were formed. The different
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De Vos, K.; et al.
Biosensors And Bioelectronics, 24, 2525-2533 (2009)
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Biomaterials, 31(16), 4592-4599 (2010-03-09)
We investigated the synergism between shRNAs against Bcl-xL and doxorubicin (DOX) using aptamer-conjugated polyplexes (APs) in combination cancer therapy. Synergistic and selective cancer cell death was achieved by AP-mediated co-delivery of very small amounts of DOX and Bcl-xL-specific shRNA, which

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