T3258

Tetracycline

98.0-102.0% (HPLC)

• Synonyme(s) : Tetracycline Hydrate
• Formule empirique (notation de Hill): C₂₂H₂₄N₂O₈ · xH₂O
• Numéro CAS: 60-54-8
• Poids moléculaire : 444.43 (anhydrous basis)
• Numéro Beilstein : 2230417
• Numéro CE : 200-481-9
• Numéro MDL: MFCD00151232
• Code UNSPSC : 51284017
• ID de substance PubChem : 24900120
• Nomenclature NACRES : NA.85

Propriétés

• Niveau de qualité: 200
• Pureté: 98.0-102.0% (HPLC)
• Forme: powder or crystals
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• Couleur: faint yellow to dark yellow
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• Clé InChI: OFVLGDICTFRJMM-WESIUVDSSA-N
• Informations sur le gène: human ... CYP1A2(1544) , TERT(7015)

Description

Description générale

Chemical structure: tetracycline

Actions biochimiques/physiologiques

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H361fd,H411
• Conseils de prudence: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves