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Key Documents

SAB4300100

Sigma-Aldrich

Anti-phospho-ATM (pSer1981) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-AT1 antibody produced in rabbit, Anti-ATA antibody produced in rabbit, Anti-ATC antibody produced in rabbit, Anti-ATD antibody produced in rabbit, Anti-ataxia telangiectasia mutated antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD01321727
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~350 kDa

Espèces réactives

human

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

Isotype

IgG

Séquence immunogène

(E-G-SP-Q-S)

Numéro d'accès NCBI

NP_000042.3

Numéro d'accès UniProt

Q13315

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer1981)

Informations sur le gène

human ... ATM(472)

Immunogène

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S), according to the protein ATM.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cyclecheckpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNArepair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cellcycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcriptvariants encoding different isoforms have been found for this gene.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Jacinta H Martin et al.
Scientific reports, 8(1), 9685-9685 (2018-06-28)
The unique biology of the oocyte means that accepted paradigms for DNA repair and protection are not of direct relevance to the female gamete. Instead, preservation of the integrity of the maternal genome depends on endogenous protein stores and/or mRNA
Yanzhu Lin et al.
Cancer cell international, 19, 129-129 (2019-05-23)
Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human cervical cancer (CC) remains unknown. The expression of PKM2
Xiao Long et al.
Journal of cellular biochemistry, 120(4), 5652-5665 (2018-11-06)
Osteosarcoma (OS) is a primary malignant bone tumor with high morbidity. Developing new therapeutic approaches with neoadjuvant is of great interest in OS treatment. Reportedly, ataxia telangiectasia mutated (ATM)/ataxia telangiectasia and radiation resistance gene 3 related (ATR)-p53 signaling is considered
Natalia Konieczna et al.
International journal of molecular sciences, 20(11) (2019-06-04)
Human telomeres were one of the first discovered and characterized sequences forming quadruplex structures. Association of these structures with oncogenic and tumor suppressor proteins suggests their important role in cancer development and therapy efficacy. Since cationic porphyrin TMPyP4 is known
Vidyavathi Reddy et al.
PloS one, 14(5), e0211090-e0211090 (2019-05-15)
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate cancer cells; this triggers
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