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P3635

Sigma-Aldrich

5β-Pregnane-3α,20α-diol glucuronide

≥98.00% (TLC), powder, progesterone metabolite

Synonyme(s) :

P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide

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About This Item

Formule empirique (notation de Hill):
C27H44O8
Numéro CAS:
1852-49-9
Poids moléculaire :
496.63
Numéro MDL:
MFCD00056522
Code UNSPSC :
51111800
ID de substance PubChem :
24898430
Nomenclature NACRES :
NA.77

Nom du produit

5β-Pregnane-3α,20α-diol glucuronide,

Stérilité

non-sterile

Essai

≥98.00% (TLC)

Forme

powder

Technique(s)

enzyme immunoassay: suitable

Solubilité

ethanol: 20 mg/mL, clear, colorless

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)

Clé InChI

ZFFFJLDTCLJDHL-UHFFFAOYSA-N

Description générale

5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.

Application

5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000419529
0000418102
0000419529
0000418102
0000407021

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Chest Pain with Normal Coronary Arteries: A Multidisciplinary Approach, 323-323 (2013)
Characterization of the ovarian cycle in the two-toed sloths (Choloepus didactylus): an innovative, reliable, and noninvasive method using fecal hormone analyses
Troll S, et al.
Theriogenology (2013)
Jennifer E Mersereau et al.
Menopause (New York, N.Y.), 15(3), 482-486 (2008-01-19)
To compare daily reproductive hormone secretion in regularly menstruating older versus younger women. This was a prospective cohort study. Daily morning urine samples were obtained from 106 women, 28 of whom were aged between 20 and 34 years (mean: 27.8+/-3.7
Kathleen A O'Connor et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18(3), 828-836 (2009-02-26)
Detailed characterization of estrogen dynamics during the transition to menopause is an important step toward understanding its potential implications for reproductive cancers developing in the transition years. We conducted a 5-year prospective study of endogenous levels of total and unopposed
Endocrine pregnancy monitoring in the two-toed sloth (Choloepus didactylus):?Pregnant or not pregnant?
Troll S, et al.
Theriogenology, 84(1), 137-144 (2015)
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