P162

Pregnenolone sulfate sodium salt

• Synonyme(s) : 3β-Hydroxy-5-pregnen-20-one 3-sulfate, 3-Hydroxypregn-5-en-20-one sulfate, 5-Pregnen-3β-ol-20-one sulfate
• Formule empirique (notation de Hill): C₂₁H₃₁NaO₅S
• Poids moléculaire : 418.52
• Numéro MDL: MFCD00056177
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278112
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Pf: 192 °C (lit.)
• Solubilité: methanol and water: 1.93 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
• Chaîne SMILES: [Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O
• InChI: 1S/C21H32O5S.Na.H/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3;;/h4,15-19H,5-12H2,1-3H3,(H,23,24,25);;/t15-,16-,17+,18-,19-,20-,21+;;/m0../s1
• Clé InChI: ABFNHVDDMHKJKK-WRHGONFGSA-N
• Informations sur le gène: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Description

Application

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

Actions biochimiques/physiologiques

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA ) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)