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G4256

Sigma-Aldrich

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast

Type IV, lyophilized powder, 20-60 units/mg protein (modified Warburg-Christian)

Synonyme(s) :

GALT, UDP glucose:α-D-galactose-1-phosphate uridyltransferase

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About This Item

Numéro CAS:
9016-11-9
Numéro de classification (Commission des enzymes):
2.7.7.12 (BRENDA, IUBMB)
Numéro MDL:
MFCD00131120
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Type

Type IV

Niveau de qualité

300

Forme

lyophilized powder

Activité spécifique

20-60 units/mg protein (modified Warburg-Christian)

Composition

Protein, 15-35%

Activité étrangère

6-phosphogluconate dehydrogenase ≤0.5%
UDP glucose pyrophosphorylase and galactokinase ≤0.2%

Température de stockage

−20°C

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Description générale

Research area: Cell Signaling

Galactose-1-phosphate uridyltransferase (GALT) is a galactose metabolizing enzyme that facilitates the simultaneous conversion of uridine diphosphoglucose (UDP-glucose) and galactose-1-phosphate (gal-1P) to uridine diphosphogalactose (UDP-galactose) and glucose-1-phosphate. Classic Galactosemia (CG) is an inherited metabolic condition caused by deficiency of GALT activity. GALT gene is mapped to human chromosome 9p13. Deficiency of GALT results in type 1 galactosemia.

Application

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast has been used to perform enzyme assays.

Définition de l'unité

One unit will form 1.0 μmole of glucose 1-phosphate from UDP-glucose, galactose 1-phosphate and NADP+ per min at pH 8.7 at 25 °C as detected by a coupled system using phosphoglucomutase.

Forme physique

Contains buffer salts as citrate and reduced glutathione

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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BMC bioinformatics, 7, 305-305 (2006-06-20)
REX1 and REX2 are protein components of the RNA editing complex (the editosome) and function as exouridylylases. The exact roles of REX1 and REX2 in the editosome are unclear and the consequences of the presence of two related proteins are
Jason G McCoy et al.
Biochemistry, 45(10), 3154-3162 (2006-03-08)
The X-ray crystal structure of the At5g18200.1 protein has been determined to a nominal resolution of 2.30 A. The structure has a histidine triad (HIT)-like fold containing two distinct HIT-like motifs. The sequence of At5g18200.1 indicates a distant family relationship
Mohamed Jama et al.
The Journal of molecular diagnostics : JMD, 9(5), 618-623 (2007-09-22)
Classic galactosemia is an autosomal recessive inherited error of galactose metabolism. It is caused by lack of galactose-1-phosphate uridyl transferase, an enzyme that is required to metabolize galactose-1-phosphate to uridine diphosphate galactose. The build up of galactose-1-phosphate is toxic at
E Crushell et al.
Journal of inherited metabolic disease, 32(3), 412-415 (2009-05-07)
Classical galactosaemia is relatively common in Ireland due to a high carrier rate of the Q188R GALT mutation. It is screened for using a bacterial inhibition assay (BIA) for free galactose. A Beutler assay on day one of life is
Daniel Lazarevic et al.
Carbohydrate research, 344(12), 1449-1452 (2009-06-30)
All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4-deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-D-lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically
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