D1413

2′,3′-Didehydro-3′-deoxythymidine

≥98% (TLC)

• Synonyme(s) : Stavudine
• Formule empirique (notation de Hill): C₁₀H₁₂N₂O₄
• Numéro CAS: 3056-17-5
• Poids moléculaire : 224.21
• Numéro MDL: MFCD00132921
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278356
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
• InChI: 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
• Clé InChI: XNKLLVCARDGLGL-JGVFFNPUSA-N

Description

Description générale

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

Application

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

Actions biochimiques/physiologiques

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)