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C2162700

Ciclopirox olamine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolammonium salt

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About This Item

Formule empirique (notation de Hill):
C12H17NO2 · C2H7NO
Numéro CAS:
41621-49-2
Poids moléculaire :
268.35
Numéro MDL:
MFCD00078997
Code UNSPSC :
41116107
ID de substance PubChem :
329774970
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

ciclopirox

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

NCCO.CC1=CC(=O)N(O)C(=C1)C2CCCCC2

InChI

1S/C12H17NO2.C2H7NO/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10;3-1-2-4/h7-8,10,15H,2-6H2,1H3;4H,1-3H2

Clé InChI

MBRHNTMUYWQHMR-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ciclopirox olamine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

C2162702

Ciclopirox impurity B, European Pharmacopoeia (EP) Reference Standard

C2162701

Ciclopirox impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000040

Ciclopirox, European Pharmacopoeia (EP) Reference Standard

1134030

Ciclopirox olamine, United States Pharmacopeia (USP) Reference Standard

1134040

Ciclopirox Related Compound B, United States Pharmacopeia (USP) Reference Standard

1134018

Ciclopirox, United States Pharmacopeia (USP) Reference Standard

1134084

Ciclopirox Related Compound C, United States Pharmacopeia (USP) Reference Standard

1134029

Ciclopirox Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1920

Ciclopirox, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2854

Ciclopirox Related Compound B, certified reference material, pharmaceutical secondary standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Sigma-Aldrich

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Sigma-Aldrich

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D Monti et al.
The British journal of dermatology, 165(1), 99-105 (2011-03-18)
Topical therapy has recently been proposed for treating onychomycosis and other nail disturbances. However, the clinical outcome may be limited by the difficulty of active ingredients effectively penetrating the nail plate. Bovine hoof membranes have been widely used to predict
Tsuyoshi Shimamura et al.
Antimicrobial agents and chemotherapy, 55(7), 3150-3155 (2011-05-11)
We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs. To establish an experimental, in vivo model
S G Jue et al.
Drugs, 29(4), 330-341 (1985-04-01)
Ciclopirox olamine is a substituted pyridone antimycotic, unrelated to the imidazole derivatives, with activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of Gram-positive and Gram-negative bacteria. The efficacy of ciclopirox olamine cream has
D Monti et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 27(2), e153-e158 (2012-03-28)
In a previous study a new hydrosoluble nail lacquer (P-3051) containing 8% ciclopirox (CPX) showed higher nail penetration compared to a water-insoluble 5% amorolfine (MRF) lacquer. To our knowledge, in vivo human data on a similar topic are not available.
Young Kim et al.
In vivo (Athens, Greece), 25(6), 887-893 (2011-10-25)
Aberrant activation of Wnt/β-catenin signaling promotes the development of several types of cancer. Recently, it has been demonstrated that Wnt pathway is also activated in myeloma. Therefore, the Wnt/β-catenin signaling molecules are attractive candidates for development of targeted therapies for
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