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Merck
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907723

Sigma-Aldrich

Azide functionalized gelatin

degree of substitution >80%

Synonyme(s) :

Azide functionlized gelatin, Azide-modified gelatin, Clickable gelatin

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About This Item

Code UNSPSC :
12352125
Nomenclature NACRES :
NA.23

Description

Degree of substitution: greater than 80% by TNBS method
NMR: Conforms to structure

Forme

powder

Couleur

white to pale yellow

Température de stockage

−20°C

Description générale

Due to its biodegradablity and biocompatibility, gelatin is routinely used in hydrogels for biomedical applications such as drug delivery, tissue engineering, and 3D bioprinting. Gelatin-based hydrogels are synthesized by the crosslinking of functionalized gelatins. Depending on the identity of the functional groups, several different processes can be used to synthesize crosslinked gelatin hydrogels, including radical-based (either thermal or photochemical) and click chemistry methods. Azide-functionalized gelatin can be used in the synthesis of hydrogels using click chemistry with alkyne-containing substrates.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Sandeep T Koshy et al.
Advanced healthcare materials, 5(5), 541-547 (2016-01-26)
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for
Vinh X Truong et al.
Biomacromolecules, 16(7), 2246-2253 (2015-06-10)
In this study, we present a method for the fabrication of in situ forming gelatin and poly(ethylene glycol)-based hydrogels utilizing bioorthogonal, strain-promoted alkyne-azide cycloaddition as the cross-linking reaction. By incorporating nitrobenzyl moieties within the network structure, these hydrogels can be
Gelatin hydrogels via thiol-ene chemistry
Russo L, et al.
Monatshefte fur Chemie / Chemical Monthly, 147, 587-592 (2016)
Thiol-yne `click?/coupling chemistry and recent applications in polymer and materials synthesis and modification.
Andrew B. Lowe
Polymer, 55 (2014)
Masato Tamura et al.
Scientific reports, 5, 15060-15060 (2015-10-10)
This paper describes the generation of "click-crosslinkable" and "photodegaradable" gelatin hydrogels from the reaction between dibenzocycloctyl-terminated photoclevable tetra-arm polyethylene glycol and azide-modified gelatin. The hydrogels were formed in 30 min through the click-crosslinking reaction. The micropatterned features in the hydrogels were
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