Click-Crosslinked Injectable Gelatin Hydrogels.

Click-Crosslinked Injectable Gelatin Hydrogels.

Advanced healthcare materials (2016-01-26)

Sandeep T Koshy, Rajiv M Desai, Pascal Joly, Jianyu Li, Rishi K Bagrodia, Sarah A Lewin, Neel S Joshi, David J Mooney

RÉSUMÉ

Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.

MATÉRIAUX

Référence du produit

Marque

Description du produit

907723

Sigma-Aldrich

Azide functionalized gelatin, degree of substitution >80%

909157

Sigma-Aldrich

Alkyne functionalized gelatin, degree of substitution > 80%