SAB4300100

Anti-phospho-ATM (pSer¹⁹⁸¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-AT1 antibody produced in rabbit, Anti-ATA antibody produced in rabbit, Anti-ATC antibody produced in rabbit, Anti-ATD antibody produced in rabbit, Anti-ataxia telangiectasia mutated antibody produced in rabbit
• MDL number: MFCD01321727
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~350 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• isotype: IgG
• immunogen sequence: (E-G-SP-Q-S)
• NCBI accession no.: NP_000042.3
• UniProt accession no.: Q13315
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer1981)
• Gene Information: human ... ATM(472)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S), according to the protein ATM.

Features and Benefits

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Target description

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cyclecheckpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNArepair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cellcycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcriptvariants encoding different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable