404888
1-Methyl-2-phenylindole
99%
Synonym(s):
NSC 63793
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About This Item
Empirical Formula (Hill Notation):
C15H13N
CAS Number:
Molecular Weight:
207.27
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
99%
mp
98-100 °C (lit.)
SMILES string
Cn1c(cc2ccccc12)-c3ccccc3
InChI
1S/C15H13N/c1-16-14-10-6-5-9-13(14)11-15(16)12-7-3-2-4-8-12/h2-11H,1H3
InChI key
SFWZZSXCWQTORH-UHFFFAOYSA-N
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General description
Reaction of 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO2-CH3COOH) in benzene has been studied. 1-Methyl-2-phenylindole is reported to react with malondialdehyde (MDA) and 4-hydroxyalkenals to afford a stable chromophore with intense maximal absorbance at 586nm.
Application
1-Methyl-2-phenylindole may be used in the following studies:
- The estimation of lipid peroxidation in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg.
- As chromogenic agent for the determination of estimation of malondialdehyde (MDA) production.
- Colorimetric assay of lipid peroxidation.
- Synthesis of 1-methyl-2-phenyl-3-(1,3,4-thiadiazol-2-yldiazenyl)-1H-indole.
- Synthesis of 3-(5-ethyl-1,3,4-thiadiazol-2-yldiazenyl)-1-methyl-2-phenyl-1H-indole.
Reactant for preparation of:
Reactant for:
- Cyano indoles
- Difluorohydroxy indoles
Reactant for:
- Carboxylation of indoles
- Allylation of indoles
- Formylation of indoles
- Nitrosylation of indoles
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Paola Astolfi et al.
Organic & biomolecular chemistry, 4(17), 3282-3290 (2006-10-13)
The reaction of 2-phenyl- and 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO2-CH3COOH) in benzene leads mainly to the formation of the isonitroso and 3-nitroso indole derivatives, respectively. When reacted with nitrous acid, 1-methyl-2-phenylindole gives also the corresponding azo-bis-indole
1-Methyl-2-phenyl-3-(1, 3, 4-thiadiazol-2-yldiazenyl)-1H-indole.
Seferoglu Z, et al.
Acta Crystallographica Section E, Structure Reports Online, 63(1), 148-150 (2007)
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Inflammatory bowel diseases are a heterogeneous group of disorders represented by two major phenotypic forms, Crohn's disease and ulcerative colitis. Cross talk between adipokines and myokines, as well as changes in intestinal microcirculation, was proposed in pathogenesis of these disorders.
M Olleros Santos-Ruiz et al.
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We previously described in cirrhosis and aging, both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with increased oxidative damage. In both conditions, the hepatic mitochondrial function was improved with low doses of IGF-1. The aim of this work
Yasir Hasan Siddique et al.
Pharmaceutical methods, 3(2), 94-97 (2013-06-20)
A method using 1-methyl-2-phenylindole was developed for the estimation of lipid peroxidation in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg (9). The method is specific for the estimation of malonaldehyde. The larvae were exposed to 0.0025, 0.025, 0.050, and
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