8.18759

Tetra-n-butylammonium hydroxide

(20% solution in water) for synthesis

• Synonym(s): N,N,N-Tributyl-1-butanaminium hydroxide, TBAH, Tetrabutylammonium hydroxide
• UNSPSC Code: 12352107
• NACRES: NA.22

Properties

• Quality Level: 200
• form: liquid
• pH: 14 (20 °C in H₂O)
• bp: 102 °C/1013 hPa
• density: 0.99 g/cm³ at 20 °C
• storage temp.: 2-30°C

Description

Application

• Hydration structures of lactic acid: Research explored the hydration structures of lactic acid and characterized the ionic clathrate hydrate formed with a biological organic acid anion, utilizing Tetra-n-butylammonium hydroxide in this process (Muromachi et al., 2014).


• Protection of ribonucleosides in RNA synthesis: A study demonstrated the use of Tetra-n-butylammonium hydroxide in the solid-phase synthesis of RNA sequences, particularly for the protection of 2′-hydroxyl groups of ribonucleosides (Cieslak et al., 2013).


• Analysis of cosmetic products: Tetra-n-butylammonium hydroxide is used as a ion-pairing agent in the simultaneous analysis of various organic acids in cosmetic products by enhancing the extraction efficiency during high-performance liquid chromatography (Mikami et al., 2002).


• Determination of calcium dobesilate in human plasma: The compound was employed in the ion-pairing extraction and high-performance liquid chromatography for the determination of calcium dobesilate in human plasma, highlighting its utility in clinical analytical methods (Rona and Ary, 2001).

Analysis Note

Assay (acidimetric): 18.0 - 22.0 %
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H314 - H317
• Precautionary Statements: P261 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3