8.18215

Tetra-n-butylammonium hydroxide

(12.5% solution in methanol) for synthesis

• Synonym(s): Tetrabutylammonium hydroxide
• UNSPSC Code: 12352107
• NACRES: NA.22

Properties

• Quality Level: 200
• expl. lim.: 5.5-36.5 % (v/v) Methanol)
• bp: 65 °C/1013 hPa
• transition temp: flash point 11 °C
• density: 0.81 g/cm³ at 20 °C
• storage temp.: 2-30°C

Description

Application

• Biological Acid Anion Research: Tetra-n-butylammonium hydroxide is used in the hydration structures of lactic acid, facilitating the formation of ionic clathrate hydrate with biological organic acid anions. This application is significant in the study of biological molecules and their interactions with water molecules in various conditions (Muromachi et al., 2014).
• Pharmaceutical Analysis: It is used in the determination of calcium dobesilate in human plasma, utilizing ion-pairing extraction and high-performance liquid chromatography. This method is crucial for monitoring drug levels in patients, ensuring therapeutic efficacy and safety (Róna et al., 2001).

Analysis Note

Assay (acidimetric): 11.5 - 13.5 %
Density (d 20 °C/ 4 °C): 0.815 - 0.830

Safety Information

• Pictograms: GHS02,GHS05,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H314 - H317 - H370
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 51.8 °F
• Flash Point(C): 11 °C