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S6942

Sigma-Aldrich

Staurosporine

from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor

Sinónimos:

Antibiotic AM-2282

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About This Item

EC Number:
200-664-3
MDL number:
MFCD04041131
UNSPSC Code:
12352200
NACRES:
NA.77

Nombre del producto

Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered

Quality Level

300

sterility

0.2 μm filtered

assay

>98% (HPLC)

concentration

1 mM in DMSO (100 μg/214 μL)

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

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General description

Chemical structure: indol derivative

Application

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4

Biochem/physiol Actions

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000209974
0000202666
059M4176V
11181138

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Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two
Maren de Vries et al.
Journal of virology (2021-02-25)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antiviral to date is remdesivir, targeting the
Dale W Hailey et al.
Cell, 141(4), 656-667 (2010-05-19)
Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in understanding the molecular basis of this process, the membrane origin of autophagosomes remains unclear. Here, we demonstrate that, in starved
G Warnes et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(3), 181-191 (2011-01-22)
The standard method of distinguishing apoptotic and oncotic cells has been by microscopic analysis of nuclei and cell membrane morphology. Thus a rapid test for analyzing large numbers of cells in the study of cell necrobiology has not been possible
Marije B Overdijk et al.
Molecular cancer therapeutics, 19(10), 2126-2138 (2020-08-28)
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies with an Fc-domain mutation that augments antibody hexamerization
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