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Key Documents

H0267

Sigma-Aldrich

Hemoglobin A0, Ferrous Stabilized human

lyophilized powder

Sinónimos:

Hemoglobin A0 Ferrous Stabilized, Hemoglobin-A0

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About This Item

Número de CAS:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42030116
NACRES:
NA.61

biological source

human

Quality Level

assay

97-100% (agarose gel electrophoresis)

form

lyophilized powder

technique(s)

immunofluorescence: suitable

solubility

H2O: soluble 20 mg/mL

suitability

suitable for electrophoresis and chromatography standard

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... HBB(3043)

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General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).

Application

Hemoglobin A0, ferrous stabilized human has been used:
  • as the non-fluorescent absorber in the preparation of tissue-mimicking phantoms
  • to see how coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
  • to study the interference of hemoglobin (Hb) A0, HbA2, and HbS in the assay of HbF

Hemoglobin A0 was used to see how coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. It was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.

Biochem/physiol Actions

Variation in the haemoglobin (Hb) encoding genes results in haemoglobinopathies such as thalassaemia and atypical structural variants like Hb Lepore and HbE.

Packaging

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Reconstitution

When reconstituted with buffer, gives >85% ferrous hemoglobin.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Perry Edwards et al.
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Ying-Chin Lin et al.
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Glycated hemoglobin (HbA1c) levels are an important index for the diagnosis and long-term control of diabetes. This study is the first to use a direct and label-free photoelectric biosensor to determine HbA1c using bacteriorhodopsin-embedded purple membranes (PM) as a transducer.
Tengfei Sun et al.
Journal of biomedical optics, 26(4) (2021-04-25)
Optical fluorescence spectroscopy technique has been explored extensively to quantify both glucose uptake and mitochondrial metabolism with proper fluorescent probes in small tumor models in vivo. However, it remains a great challenge to rapidly quantify the intrinsic metabolic fluorophores from
Hanna Jonasson et al.
Journal of biomedical optics, 27(7) (2022-02-03)
Tissue simulating phantoms are an important part of validating biomedical optical techniques. Tissue pathology in inflammation and oedema involves changes in both water and hemoglobin fractions. We present a method to create solid gelatin-based phantoms mimicking inflammation and oedema with
Seung Yup Lee et al.
Science advances, 6(47) (2020-11-22)
Pancreatic cancer is one of the deadliest cancers, with a 5-year survival rate of <10%. The current approach to confirming a tissue diagnosis, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), requires a time-consuming, qualitative cytology analysis and may be limited because of

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