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38534

Sigma-Aldrich

Polylactic acid

Mw ~60,000

Sinónimos:

Poly(2-hydroxypropionic acid)

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About This Item

Número de CAS:
26100-51-6
MDL number:
MFCD00081867
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

shelf life

limited shelf life, expiry date on the label

mol wt

Mn ~30,000
Mw ~60,000

InChI

1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)

InChI key

JVTAAEKCZFNVCJ-UHFFFAOYSA-N

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General description

Polylactic acid(PLA) is a biodegradable polyester synthesized from lactic acid monomer via ring opening polymerization. Owing to its excellent thermal, mechanical and barrier properties, it is widely used in the field of tissue engineering, drug delivery, and orthopedic devices.

Application

Polylactic acid can be used to prepare tubular scaffolds via the electrospinning method. These scaffolds are applicable in vascular tissue engineering.

It can be used to prepare PLA/polyvinyl alcohol wound dressing membrane through electrospinning and coating method. The coating of PLA improves the mechanical strength of nanofiber and acts as a protective layer to control the release of drug to the wound site.

It can also be used to synthesize free-standing, flexible ultra-thin PLA nanofilms which can act as a matrix for adhesion, spreading, and proliferation of skeletal muscle cells.

Features and Benefits

  • Biocompatibility
  • Lower toxicity
  • Low cost
  • Better encapsulation

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCM4836
BCCM4837
BCCM1898
BCCM1900
BCCL7978

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Huan Zhou et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2302-2310 (2013-03-19)
Fibrous bionanocomposites consisting of amorphous magnesium phosphate (AMP) nanospheres and polylactic acid (PLA) were fabricated by electrospinning. There are two important signatures of this paper. First, AMP, as an alternative to well-known calcium phosphate (CaP) materials, is added to PLA
Tong Chen et al.
Carbohydrate polymers, 92(2), 1124-1132 (2013-02-13)
Core-shell structured multifunctional nanocarriers (NCs) of ZnO quantum dots-conjugated gold nanoparticles (Au NPs) as core and amphiphilic hyperbranched block copolymer as shell were synthesized for targeted anticancer drug delivery. The amphiphilic hyperbranched block copolymer contained poly(l-lactide) (PLA) inner arm and
R M Felfel et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 1914-1924 (2013-03-19)
Fibre reinforced composites have recently received much attention as potential bone fracture fixation applications. Bioresorbable composites based on poly lactic acid (PLA) and phosphate based glass fibre were investigated according to ion release, degradation, biocompatibility and mechanical retention profiles. The
Paul S Rosen et al.
Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 34(1), 34-38 (2013-04-05)
This retrospective case series reports on the use of a polylactic acid barrier that was left exposed in the process of socket preparation for the placement of dental implants. A retrospective chart review found 43 patients with 48 extraction sockets
Nomaan M Rezayee et al.
Dalton transactions (Cambridge, England : 2003), 42(15), 5573-5586 (2013-02-26)
A series of NNO ketoimines bearing trifluoromethyl substituents were synthesized from the Schiff base condensation of 1,3-diketones (1,1,1-trifluoro-5,5-dimethyl-2,4-hexanedione, 4,4,4-trifluoro-1-phenyl-1,3-butanedione, and 1,1,1-trifluoro-2,4-pentanedione, 1,1,1,5,5,5-hexafluoroacetylacetone) and 8-aminoquinoline or 8-amino-2-methylquinoline and isolated in 40-70% yield. The ketoimines were combined with zinc bis-(trimethylsilyl)amide to prepare
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