676950-M

Veratridine

≥98% (TLC), solid, Na⁺ channel opener, Calbiochem

• Synonym(s): Veratridine
• Empirical Formula (Hill Notation): C₃₆H₅₁NO₁₁
• CAS Number: 71-62-5
• Molecular Weight: 673.79
• MDL number: MFCD00082515
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Veratridine, A Na⁺ channel opener.
• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to yellow
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
• InChI key: FVECELJHCSPHKY-YFUMOZOISA-N

Description

General description

A Na⁺ channel opener. Increases intracellular Ca²⁺ levels without affecting Na⁺ - Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

A Na⁺ channel opener. Increases intracellular Ca²⁺ levels without affecting Na⁺-Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

Biochem/physiol Actions

Primary Target
Na+ channel

Warning

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331.
Plattner, H., et al. 1994. J. Membr. Biol. 142, 229.
Rando, T.A., et al. 1989. J. Gen. Physiol.93, 43.
Rando, T.A., et al. 1986. Mol. Pharmacol.29, 467.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H319,H335
• pcodes: P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable