1.00590

Glycine

crystalline, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonym(s): Glycine, Gly, Aminoacetic acid, Aminoethanoic acid, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein/REAXYS Number: 635782
• MDL number: MFCD00008131
• UNSPSC Code: 12352121
• EC Index Number: 200-272-2

Properties

• agency: BP; ChP; JP; Ph. Eur.; USP
• Quality Level: 500
• vapor pressure: 0.0000171 Pa ( 25 °C)
• description: EMPROVE^® EXPERT Ph Eur,BP,JP,USP
• product line: EMPROVE^® EXPERT
• assay: 98.5-101.0% (calculated on dried substance, perchloric acid titration)
• form: crystalline; solid
• technique(s): inhibition assay: suitable
• pH: 5.9-6.4 (20 °C, 50 g/L in H₂O)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• solubility: soluble 250 g/L
• density: 1.161 g/cm³ at 20 °C
• application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• storage temp.: 2-30°C
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• Inchi Key: DHMQDGOQFOQNFH-UHFFFAOYSA-N

Description

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Glycine is an amino acid which is used widely in the biopharma industry as stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine cryst. Emprove^® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 1.00590 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable