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T2896

Sigma-Aldrich

Triflupromazine hydrochloride

Sinónimos:

N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine monohydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H19F3N2S · HCl
Número de CAS:
1098-60-8
Peso molecular:
388.88
Beilstein/REAXYS Number:
3801519
EC Number:
214-149-6
MDL number:
MFCD00058103
UNSPSC Code:
12352200
PubChem Substance ID:
24278730

SMILES string

Cl.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F

InChI

1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FTNWXGFYRHWUKG-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813)

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Application

Triflupromazine hydrochloride has been used for the screening of inhibitors of S. mansoni miracidial transformation5. It has also been used to study its intracellular localization in central nervous system cells using secondary ion mass spectrometry microscopy6.

Biochem/physiol Actions

Triflupromazine is a D2 dopamine antagonist and a phenothiazine antipsychotic. It is also a potent tranquilizer7 and can significantly reduce body temperature8.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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A study of triflupromazine in dominant-lethal, cytogenetic and host-mediated assays.
V A Ray et al.
Mutation research, 18(3), 301-309 (1973-06-01)
D Jovanović-Mićić et al.
European journal of pharmacology, 272(1), 21-30 (1995-01-05)
Intracerebroventricular injection of dopamine (0.5-4.0 mg) produced dose-dependent and short-lasting emesis (1-8 min) in cats, which was abolished after ablation of the area postrema. Relatively selective alpha 2-adrenoceptor antagonists (yohimbine and idazoxan) and a mixed alpha 1- and alpha 2-adrenoceptor
L L Zhang et al.
Biology of the cell, 74(1), 99-103 (1992-01-01)
The intracellular localization of two neurotropic drugs, flunitrazepam (benzodiazepine) and triflupromazine (phenothiazine), was studied by secondary ion mass spectrometry microscopy (SIMS) in three varieties of cells. The images of the intracellular distributions of the two drugs are easily obtained by
The structure of triflupromazine, a phenothiazine 'tranquilizer' drug molecule.
Phelps, D. W., and Cordes, A. W.
Acta Crystallographica Section B, Structural Crystallography and Crystal Chemistry, 30(12), 2812-2816 (1974)
M Tatsumi et al.
European journal of pharmacology, 368(2-3), 277-283 (1999-04-08)
Using radioligand binding techniques, we determined the equilibrium dissociation constants (K(D)) for 37 neuroleptics and one metabolite of a neuroleptic (haloperidol metabolite) for the human serotonin, norepinephrine, and dopamine transporters with [3H]imipramine, [3H]nisoxetine, and [3H]WIN35428, respectively. Among neuroleptics, the four
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