SRP6312
Alpha 1 Antitrypsin from human plasma
HBsAg, HCV, HBc free, ≥95% (SDS-PAGE)
Sinónimos:
AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, PI, Serpin A1
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
human
Ensayo
≥95% (SDS-PAGE)
Formulario
lyophilized
potencia
≥5.0 I.U. per mg
mol peso
52 kDa
envase
pkg of 1 mg
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... Serpin A1(5265)
Descripción general
Our Alpha 1 Antitrypsin is a human plasma protein.It is shown to be HBsAg, HCV, HBc free and also negative for anti HIV1 and HIV2 according to FDA approved tests.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1. AAT is an acute-phase plasma protein. It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells. AAT is also referred to as Serpin A1.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1. AAT is an acute-phase plasma protein. It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells. AAT is also referred to as Serpin A1.
Aplicación
AAT (α 1 antitrypsin) from human plasma has been used as a standard to check the presence of AAT in benign and malignant lymphoreticular cells and tissues.
Acciones bioquímicas o fisiológicas
AAT (α 1 antitrypsin) functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of AAT and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in AAT occurs as an acute phase response to tissue necrosis and inflammation. It might work as a biomarker for cutaneous squamous cell carcinoma, hepatitis B, insulinomas, NSCLC (non-small cell lung cancer), papillary thyroid carcinoma, lung cancer and breast carcinoma.
Forma física
Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
Reconstitución
In water or aqueous buffer
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.
Schaefer B
Human Molecular Genetics, 24, 6254-6263 (2015)
Alpha 1 antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z. A survey by the British Thoracic Association.
Tobin MJ
British Journal of Diseases of the Chest, 77, 14-27 (1983)
Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
Wang Q
Scientific Reports, 5, doi: 10-doi: 10 (2015)
SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients.
Chan HJ
Oncotarget, 6, 25815-25827 (2015)
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
Carrell RW
The Journal of Clinical Investigation, 78, 1427-1431 (1986)
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