SRP0463
BRD4, BD1, BD2 (49-460) GST tag human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sinónimos:
CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
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100 μG
$710.00
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100 μG
$710.00
About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Productos recomendados
biological source
human
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
aqueous solution
mol wt
73.3 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BRD4(23476)
General description
BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.[1][2]
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_ NM_058243) amino-acids 49-460 with N-terminal GST-tag, MW = 73.3kDa, expressed in an Escherichia coli expression system.
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_ NM_058243) amino-acids 49-460 with N-terminal GST-tag, MW = 73.3kDa, expressed in an Escherichia coli expression system.
Biochem/physiol Actions
BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease.[1][2] This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis.[2] BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.[3]
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A.
Williams FP, et al.
PLoS ONE, 11, e0154607-e0154607 (2016)
High level of BRD4 promotes non-small cell lung cancer progression.
Liao YF, et al.
Oncotarget, 7, 9491-9491 (2016)
BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma.
Zhang P, et al.
International Journal of Immunopathology and Pharmacology, 28, 36-36 (2015)
R M Rodriguez et al.
Journal of molecular medicine (Berlin, Germany), 90(5), 587-595 (2011-11-29)
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human
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