SML1681

Endosidin2

≥98% (HPLC)

• Sinónimos: (E)-3-Fluoro-N′-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide
• Fórmula empírica (notación de Hill): C₁₅H₁₂FIN₂O₃
• Número de CAS: 1839524-44-5
• Peso molecular: 414.17
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826011
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=CC(C(N/N=C/C2=CC(OC)=C(O)C(I)=C2)=O)=CC=C1
• InChI: 1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
• InChI key: UIADDCURKKFTFW-QGMBQPNBSA-N

Descripción

Biochem/physiol Actions

Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd = 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.  

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable