B5936

Brefeldin A

Name: Brefeldin A
Brand: SIGMA
Price: 145 USD

Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

Sinónimos:

Synergisidin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

Slide 1 of 1

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

200 μL

$145.00

Comprobar disponibilidad del carrito

Solicite una orden a granel

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₆H₂₄O₄

Número CAS:

20350-15-6

Peso molecular:

280.36

UNSPSC Code:

51102829

NACRES:

NA.85

PubChem Substance ID:

329773270

MDL number:

MFCD12913297

Beilstein/REAXYS Number:

25191

Documentos clave

Ver Toda la documentación

Saltar a

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

InChI key

KQNZDYYTLMIZCT-KQPMLPITSA-N

SMILES string

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

biological source

Penicillium brefeldianum

vapor pressure

0.56 hPa ( 20 °C)

form

ready-to-use solution

autoignition temp.

301 °C

concentration

10 mg/mL in DMSO

solubility

DMSO: 10 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

2-8°C

Quality Level

200

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Chemistry & Biochemicals

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo	B6542	B7651	M3536
Sigma-Aldrich B5936 Brefeldin A	Sigma-Aldrich B6542 Brefeldin A	Sigma-Aldrich B7651 Brefeldin A	Sigma-Aldrich M3536 Mycophenolic acid
antibiotic activity spectrum neoplastics	antibiotic activity spectrum neoplastics	antibiotic activity spectrum neoplastics	antibiotic activity spectrum -
mode of action cell membrane \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action enzyme \| inhibits
Quality Level 200	Quality Level 300	Quality Level 300	Quality Level 300
form solution	form powder	form powder	form powder
biological source Penicillium brefeldianum	biological source Penicillium brefeldianum	biological source Penicillium brefeldianum	biological source Penicillium brevicompactum
concentration 10 mg/mL in DMSO	concentration -	concentration -	concentration -

Application

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.[1] BFA inhibits the transport of sphingomyelin to the surface of mammalian cells.[2] The ester derivatives of BFA exhibit anti-cancer properties.[3]

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Hygroscopic.Storage class (TRGS 510): Combustible liquids

Clase de almacenamiento

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Antiviral activity of brefeldin A and verrucarin A.

G Tamura et al.

The Journal of antibiotics, 21(2), 160-161 (1968-02-01)

Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity.

A van Helvoort et al.

Journal of cell science, 110 ( Pt 1), 75-83 (1997-01-01)

Sphingomyelin is a major lipid of the mammalian cell surface. The view that sphingomyelin, after synthesis in the Golgi lumen, reaches the outer leaflet of the plasma membrane on the inside of carrier vesicles has been challenged by inconsistencies in

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.

Marco Lepore et al.

Nature communications, 5, 3866-3866 (2014-05-17)

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Jan H Reiling et al.

Nature cell biology, 15(12), 1473-1485 (2013-11-05)

Treatment of cells with brefeldin A (BFA) blocks secretory vesicle transport and causes a collapse of the Golgi apparatus. To gain more insight into the cellular mechanisms mediating BFA toxicity, we conducted a genome-wide haploid genetic screen that led to

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.

Priya Rajavelu et al.

The Journal of clinical investigation, 125(5), 2021-2031 (2015-04-14)

Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens that are inhaled throughout life. The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells

Ver todos los artículos relacionados

Questions

1–3 of 3 Questions

Anonymous

8 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  8 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

a year ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  a year ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
Anonymous

2 years ago

How stable is the solution if kept at 4 ºC? thanks

1 answer
1. Technical Support
  
  2 years ago
  
  This product is a 10 mg/mL solution in DMSO. The recommended storage temperature is 2-8°C. Assuming proper handling and storage, the item will be stable until the recommended retest date reported on the lot specific Certificate of Analysis. The product is assigned a retest date of 2 years from the date of Quality Release.
  
  Helpful?

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico