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SML0956

Sigma-Aldrich

Dexmedetomidine hydrochloride

≥98% (HPLC)

Sinónimos:

(+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride, 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

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10 MG
$113.05
50 MG
$501.00

$113.05

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10 MG
$113.05
50 MG
$501.00

About This Item

Fórmula empírica (notación de Hill):
C13H16N2 · HCl
Número de CAS:
145108-58-3
Peso molecular:
236.74
Código UNSPSC:
12352200
NACRES:
NA.77

$113.05

Precio de catálogo$119.00Ahorre 5 %
Web-Only Promotion

Disponible para envío el07 de abril de 2025Detalles

Solicitar un pedido a granel

Ensayo

≥98% (HPLC)

Formulario

powder

actividad óptica

[α]/D +48 to +58°, c = 1 in H2O

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: 20 mg/mL, clear

temp. de almacenamiento

2-8°C

cadena SMILES

[Cl-].[N+H2]1C=NC=C1[C@@H](C)c2c(c(ccc2)C)C

InChI

1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

Clave InChI

VPNGEIHDPSLNMU-MERQFXBCSA-N

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Aplicación

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.[1][2]

Acciones bioquímicas o fisiológicas

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.
Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palabra de señalización

Warning

Frases de peligro

H302,H336,H411

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

Órganos de actuación

Central nervous system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000175475
0000175475
0000129538
0000129539
0000114620

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Zheng-Tao Zhang et al.
Inflammopharmacology, 31(1), 423-438 (2022-12-20)
To explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI. C57BL/6 mice and EL-4 cells were used in this research. The ALI model was established by CLP. The level of inflammatory cytokines in the lung and blood
Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes
Ke Peng
Experimental and Therapeutic Medicine (2017)
Cheng Chen et al.
Oxidative medicine and cellular longevity, 2022, 7511393-7511393 (2022-05-10)
Parkinson's disease (PD) is a common neurodegenerative disease characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Our previous study has shown that dexmedetomidine (Dex) can protect mitochondrial function and reduce apoptosis in MPP+-induced SH-SY5Y cells.
Anna K Shoveller et al.
Journal of feline medicine and surgery, 16(12), 957-965 (2014-03-15)
Body condition scoring (BCS) provides a readily available technique that can be used by both veterinary professionals and owners to assess the body condition of cats, and diagnose overweight or underweight conditions. The objective of this study was to evaluate
Jia Liao et al.
International journal of molecular sciences, 22(23) (2021-12-11)
Dexmedetomidine (DEX), a selective α2 adrenergic receptor (AR) agonist, is commonly used as a sedative drug during critical illness. In the present study, we explored a novel accelerative effect of DEX on cardiac fibroblast (CF) differentiation mediated by LPS and
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