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C7897

Clonidine hydrochloride

Name: Clonidine hydrochloride
Brand: SIGMA
Price: 63.1 USD

α2-adrenoceptor agonist, solid

Sinónimos:

2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride

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Talla/SKU	Disponibilidad	Precio
100 mg	Comprobar disponibilidad del carrito	$63.10
250 mg	Comprobar disponibilidad del carrito	$164.00
1 g	Comprobar disponibilidad del carrito	$501.00
5 g	Comprobar disponibilidad del carrito	$1,470.00

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₉H₉Cl₂N₃ · HCl

Número CAS:

4205-91-8

Peso molecular:

266.55

NACRES:

NA.77

PubChem Substance ID:

24277750

UNSPSC Code:

12352200

EC Number:

224-121-5

MDL number:

MFCD00036705

Beilstein/REAXYS Number:

4163525

Form:

solid

$63.10

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Propiedades

Nombre del producto

Clonidine hydrochloride, solid

form

solid

Quality Segment

100

color

white

solubility

H₂O: soluble, methanol: soluble

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

Cl[H].Clc1cccc(Cl)c1NC2=NCCN2

InChI

1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

InChI key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Descripción

General description

Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.

Application

Clonidine hydrochloride has been used:

to reduce central noradrenaline levels
to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
to attenuate thermal and mechanical pain hypersensitivity in rats
as a positive control for pertussis toxin (PTX)

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:

in ex vivo leptin release assay
to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
to study its influence on the sleep of larval zebrafish
to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation

Biochem/physiol Actions

α₂-adrenoceptor agonist; I₁ imidazoline binding site ligand.

Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Este artículo	C2400000	PHL80201	L5647
Sigma-Aldrich C7897 Clonidine hydrochloride	C2400000 Clonidine hydrochloride	PHL80201 Coniine hydrochloride	Sigma-Aldrich L5647 Lidocaine hydrochloride monohydrate
description solid	description European Pharmacopoeia (EP) Reference Standard	description phyproof^® Reference Substance	description solid
form solid	form -	form -	form solid
Quality Level 100	Quality Level -	Quality Level -	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
solubility H₂O: soluble, methanol: soluble	solubility -	solubility -	solubility H₂O: soluble
color white	color -	color -	color white
Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information -	Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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pictograms

GHS06

signalword

Danger

hcodes

H301,H330

pcodes

P301 + P310 + P330 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c