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SML0044

Tubastatin A hydrochloride

≥98% (HPLC), Selective HDAC6 inhibitor, powder

Sinónimos:

N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried; N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride

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Talla/SKUDisponibilidadPrecio
5 mg
Comprobar disponibilidad del carrito
$232.00
25 mg
Comprobar disponibilidad del carrito
$887.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C20H21N3O2·HCl
Número CAS:
Peso molecular:
371.86
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$232.00


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Nombre del producto

Tubastatin A hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl

InChI

1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

InChI key

LJTSJTWIMOGKRJ-UHFFFAOYSA-N

Application

Tubastatin A hydrochloride may be used in HDAC6-mediated cell signaling studies.

Biochem/physiol Actions

Tubastatin A Hydrochloride is a very selective HDAC6 inhibitor.
Tubastatin A is a very selective HDAC6 inhibitor with an IC50 of 4 nM and 100 to over 1000-fold selectivity for HDAC6 over other HDAC classes.
Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Este artículo
382187M7316SRP3003
description

≥98% (HPLC)

description

The HDAC Inhibitor XXIII, Tubastatin A controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

recombinant, expressed in baculovirus infected BTI insect cells

description

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

-

assay

≥97% (HPLC), ≥97% (SDS-PAGE)

form

powder

form

solid

form

liquid

form

lyophilized

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage condition

desiccated

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: 250 μg/mL

solubility

-

solubility

-


Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable



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