S0445

Anti-Serotonin 5-HT_2B Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-5-HT(2B), Anti-5-HT-2B, Anti-5-HT2B
• MDL number: MFCD01865274
• UNSPSC Code: 12352203

Propiedades

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• availability: not available in Japan
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-6 μg/mL using human brain, neurons and glia
• UniProt accession no.: P41595
• shipped in: wet ice
• storage temp.: −70°C
• target post-translational modification: unmodified
• Gene Information: human ... HTR2B(3357) ; mouse ... Htr2b(15559) ; rat ... Htr2b(29581)

Descripción

General description

Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.

Immunogen

synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT_2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.

Biochem/physiol Actions

The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.

Target description

The Serotonin 5-HT_2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT_2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.

Physical form

solution in phosphate buffered saline containing ≤0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable