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MAK036

Sigma-Aldrich

Hemin Assay Kit

sufficient for 100 colorimetric tests

Sinónimos:

Hemin Quantitative Test Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 colorimetric tests

application(s)

cosmetics
food and beverages

detection method

colorimetric

relevant disease(s)

immunological diseases; rheumatological diseases; gastrointestinal diseases; cardiovascular diseases

storage temp.

2-8°C

General description

Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.

Application

Hemin Assay Kit has been used to determine the level of free hemin (oxidized heme).

Suitability

Suitable for use with cell and tissue culture supernatants, urine, plasma, serum, fecal material, media, and other biological fluids.

Principle

In this assay, Hemin concentration is determined by a coupled enzyme reaction, which results in a colorimetric (570 nm) product, proportional to the Hemin present.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number
8L09K06720
8G15K06720
8C28K06720
8G20K06720
7K11K06720

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Guangjian Yang et al.
Open life sciences, 16(1), 930-936 (2021-09-24)
Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Fader K A, et al.
Toxicology and Applied Pharmacology, 321, 1-17 (2017)
Kelly A Fader et al.
Toxicology and applied pharmacology, 321, 1-17 (2017-02-19)
Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated
Characterization of novel inhibition of indoleamine 2, 3-dioxygenase by targeting its apo form.
Ortiz-Meoz R F, et al.
bioRxiv, 324947-324947 (2018)
Laura Casares et al.
Redox biology, 28, 101321-101321 (2019-09-14)
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical benefits of CBD in humans have been extensively
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