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Merck

MAK033

Sigma-Aldrich

ADP Colorimetric/Fluorometric Assay Kit

sufficient for 100 colorimetric or fluorometric tests

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.84

uso

sufficient for 100 colorimetric or fluorometric tests

método de detección

colorimetric
fluorometric

temp. de almacenamiento

−20°C

Descripción general

The new ADP Assay Kit, MAK518, is now available! Adenosine diphosphate (ADP) is a nucleoside diphosphate that plays a critical role in energy transfer reactions. ADP is produced from adenosine triphosphate (ATP) via the action of ATPases. ADP also plays a critical role in platelet function. ADP, stored in platelet-dense granules, is released upon platelet activation where it acts on purinergic receptors to mediate intracellular signaling and platelet aggregation. ADP is a key agonist involved in thrombosis and hemostasis.

Características y beneficios

Compatible with high-throughput handling systems.

Idoneidad

Suitable for the measuerement of ADP in a variety of biological samples including cell and tissue lysates

Principio

In this assay, ADP (adenosine diphosphate) concentration is determined by a coupled enzyme reaction, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the ADP present.

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Referencia del producto
Descripción
Precios

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

188.6 °F - closed cup

Punto de inflamabilidad (°C)

87 °C - closed cup


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Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression.
Renshaw P F, et al.
The American Journal of Psychiatry, 158(12), 2048-2055 (2001)
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.
Foster C J, et al.
The Journal of Clinical Investigation, 107(12), 1591-1598 (2001)
Ana Luisa Palacios-Acedo et al.
Frontiers in oncology, 11, 704945-704945 (2021-10-01)
Platelet function can be modified by cancer cells to support tumor growth, causing alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are one of the main pillars of Trousseau's syndrome: a paraneoplastic syndrome with recurring and migrating episodes
ADP is not an agonist at P2X1 receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets.
Mahaut-Smith M P, et al.
British Journal of Pharmacology, 131(1), 108-114 (2000)
Sophie Hallakou-Bozec et al.
PloS one, 16(2), e0241651-e0241651 (2021-02-20)
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes. Imeglimin, a novel first-in-class small molecule tetrahydrotriazine drug candidate, improves glycemia and GSIS in preclinical models and clinical

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