This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S. for use solely for preclinical researchy purposes (i.e., not for the administration to or other use in humans).
The Journal of pharmacology and experimental therapeutics, 283(2), 636-647 (1997-11-14)
L-745,870,(3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H- pyrollo[2,3-b] pyridine, was identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and brain penetration. L-745,870 displaced specific binding of 0.2 nM [3H] spiperone to cloned human dopamine D4 receptors with a binding affinity (Ki) of
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