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J4829

Sigma-Aldrich

JFD00244

≥98% (HPLC), solid

Sinónimos:

1,4-bis[(p-hydroxyphenethyl)amino]-anthraquinone

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About This Item

Fórmula empírica (notación de Hill):
C30H26N2O4
Número de CAS:
96969-83-4
Peso molecular:
478.54
MDL number:
MFCD00208443
UNSPSC Code:
12352202
PubChem Substance ID:
329815737

assay

≥98% (HPLC)

form

solid

color

violet

solubility

DMSO: ≥10 mg/mL
H2O: <2 mg/mL

storage temp.

room temp

SMILES string

Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c4C(=O)c5ccccc5C(=O)c24)cc1

InChI

1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2

InChI key

UUJHFIBEJJLZBF-UHFFFAOYSA-N

Biochem/physiol Actions

JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Anu J Tervo et al.
Journal of medicinal chemistry, 47(25), 6292-6298 (2004-11-30)
Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of
Anu J Tervo et al.
Journal of medicinal chemistry, 49(24), 7239-7241 (2006-11-28)
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of these

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