I4401
Interferon-αA/D human
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Sinónimos:
IFN-αA/D
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100000 UNITS
$551.00
$551.00
Fecha estimada de envío24 de marzo de 2025
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100000 UNITS
$551.00
About This Item
$551.00
Fecha estimada de envío24 de marzo de 2025
Productos recomendados
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥95%
form
buffered aqueous solution
mol wt
19 kDa
packaging
pkg of 100K units
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IFNA2(3440)
Application
Interferon-αA/D human has been used:
- for identification of coronavirus replicase inhibitors[1]
- in combination with ACH-806 [1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea] to study the effect on hepatitis C virus (HCV) replication[2]
- in combination with vitamin D to check reduction in HCV protein production in cell culture[3]
Biochem/physiol Actions
Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Physical form
Solution in phosphate buffered saline containing 0.1% bovine serum albumin
Analysis Note
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV).[4][5] A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA.[6]
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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David L Wyles et al.
Antimicrobial agents and chemotherapy, 52(5), 1862-1864 (2008-03-12)
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside
Julio A Gutierrez et al.
Journal of virology & antiviral research, 3(3), doi:10-doi:10 (2015-11-26)
Previous studies suggest that low serum 25-hydroxyvitamin D [25(OH) D] levels are associated with reduced responsiveness to interferon and ribavirin therapy. We investigated the impact of vitamin D metabolites on HCV and cellular gene expression in cultured hepatoma cells. HCV
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Journal of virology, 96(11), e0036422-e0036422 (2022-05-20)
Effective broad-spectrum antivirals are critical to prevent and control emerging human coronavirus (hCoV) infections. Despite considerable progress made toward identifying and evaluating several synthetic broad-spectrum antivirals against hCoV infections, a narrow therapeutic window has limited their success. Enhancing the endogenous
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Antiviral research, 161, 1-9 (2018-10-28)
Rabies virus transmits from animals to humans and causes encephalitis. Every year more than 15 million people receive a post exposure prophylaxis (PEP) treatment that is highly effective in the prevention of rabies disease. However, when clinical symptoms appear, for
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