I1392
HA-100
Sinónimos:
1-(5-Isoquinolinesulfonyl)piperazine hydrochloride
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About This Item
Fórmula empírica (notación de Hill):
C13H15N3O2S
Número de CAS:
Peso molecular:
277.34
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
storage temp.
−20°C
SMILES string
Cl.O=S(=O)(N1CCNCC1)c2cccc3cnccc23
Gene Information
human ... MYLK(4638) , MYLK2(85366)
Biochem/physiol Actions
Inhibitor of PKA, PKC and myosin light chain kinase.
Quality
HCl content may vary.
Analysis Note
Actual content given on the label
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
J T O'Flaherty et al.
Biochemical and biophysical research communications, 163(3), 1456-1460 (1989-09-29)
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to
Regulation of neutrophil chemotaxis: correlations with actin polymerization.
L Harvath
Cancer investigation, 8(6), 651-654 (1990-01-01)
M Awazu et al.
Journal of cardiovascular pharmacology, 17 Suppl 7, S500-S502 (1991-01-01)
The vasoconstrictor response is defective in diabetes mellitus (DM). Activation of protein kinase C (PKC) is also known to prevail in diabetes mellitus, and it is thought to be secondary to abnormal diacylglycerol metabolism. To ascertain whether this PKC activation
L Harvath et al.
Journal of immunology (Baltimore, Md. : 1950), 139(9), 3055-3061 (1987-11-01)
The protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine (C-I), inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol, without inhibiting superoxide release from PMN stimulated with the chemoattractants C5a or N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). In this study, we
S Daniels et al.
Comparative biochemistry and physiology. Comparative physiology, 105(4), 659-665 (1993-08-01)
1. The standard O2-paradox has been studied in the Langendorff-perfused rat heart. 2. Perfusion of glucose-free saline under anoxia did not cause release of creatine kinase (CK) although, it is suggested, there was a progressive rise in [Ca2+]i. 3. Ca(2+)-depletion
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