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GW20021F

Sigma-Aldrich

Anti-Fibronectin Antibody

chicken polyclonal

Sinónimos:

Anti-Cold-insoluble globulin, Anti-FN

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About This Item

MDL number:
MFCD00162291
UNSPSC Code:
12352203
NACRES:
NA.41

product name

Anti-Fibronectin antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-20021F

concentration

1.0-1.2 mg/mL

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

CAA26536.1

UniProt accession no.

P02751

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FN1(2335)

General description

The gene FN1 (Fibronectin) is mapped to human chromosome 2q34. It is present as a soluble dimeric form in plasma. At the cell surface and in the extracellular matrix, it is present as a dimeric or multimeric form.

Immunogen

Fibronectin native protein.
Immunogen Sequence: GI # 31397, sequence 1-2328

Application

Anti-Fibronectin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

Biochem/physiol Actions

Fibronectin (FN1) is a glycoprotein that is involved in cell adhesion and migration processes, such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis. It binds to cell surfaces and compounds, such as collagen, fibrin, heparin, fibulin, integrins, cell adhesive mac-2 binding protein (M2BP), cartilage oligomeric matrix protein (COMP), DNA, and actin. Fibronectin interaction with FLRG (Follistatin-related gene protein) and follistatin is important for human hematopoietic cell adhesiveness. It is associated with glomerulopathy with fibronectin deposits, an autosomal dominant disease. Polymorphism in gene is linked with increased risk of knee osteoarthritis. Human pathogens, Staphylococcus aureus and Streptococcus pyogenes, target fibronectin for adhesion to and invasion of host cells. Pigment epithelium-derived factor (PEDF) down-regulates fibronectin to suppress breast cancer metastasis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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R Carlsson et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(4), 2403-2406 (1981-04-01)
Laminin, a basement membrane glycoprotein isolated from cultures of mouse endodermal cells and rat yolk sac carcinoma cells, promoted the attachment of liver cells obtained from regenerating mouse liver. Cells from normal mouse liver attached readily to dishes coated with
Mohamed Reda Fazazi et al.
Nature communications, 15(1), 5404-5404 (2024-06-27)
B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH[MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon immunization with the T cell-obligate autoantigen, MOG[35-55], IgH[MOG] mice develop
C Ffrench-Constant et al.
The Journal of cell biology, 109(2), 903-914 (1989-08-01)
The adhesive extracellular matrix glycoprotein fibronectin (FN) is thought to play an important role in the cell migration associated with wound healing. Immunolocalization studies show abundant FN in healing wounds; however, these studies cannot define the cellular site(s) of FN
E Engvall et al.
International journal of cancer, 20(1), 1-5 (1977-07-15)
Fibronectin, a plasma protein immunologically identical with a major surface protein of normal fibroblasts, was found to bind to collagen and gelatin. A solid phase enzyme immunoassay was used for the binding tests. Collagen, gelatin or various control proteins were
Véronique Maguer-Satta et al.
Experimental cell research, 312(4), 434-442 (2005-12-13)
FLRG and follistatin belong to the family of follistatin proteins involved in the regulation of various biological effects, such as hematopoiesis, mediated by their binding to activin and BMP, both members of the TGFbeta family. To further characterize the function
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