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E9386

5-Ethyl-2′-deoxyuridine

≥95% (HPLC), synthetic (organic), powder

Sinónimos:

EUdR, Edoxudine

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Tamaño de envaseSKUDisponibilidadPrecio
250 mg

Envío estimado HOYdesdeMILWAUKEE

$391.00
$332.35
1 g
Comprobar disponibilidad del carrito
$959.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C11H16N2O5
Número CAS:
15176-29-1
Peso molecular:
256.26
EC Number:
239-226-1
MDL number:
MFCD00079191
NACRES:
NA.51
PubChem Substance ID:
24894696
UNSPSC Code:
41106305
Assay:
≥95% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless to yellow
Storage temp.:
−20°C

$332.35

Precio de catálogo$391.00Ahorre 15 %
Promoción solo por Internet

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Nombre del producto

5-Ethyl-2′-deoxyuridine,

biological source

synthetic (organic)

Quality Level

200

assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow

storage temp.

−20°C

SMILES string

CCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O

InChI

1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)

InChI key

XACKNLSZYYIACO-UHFFFAOYSA-N

Biochem/physiol Actions

5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.
5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.

Other Notes

Homolog of thymidine

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Este artículo
D5412D5782I7125
5-Ethyl-2′-deoxyuridine

Sigma-Aldrich

E9386

5-Ethyl-2′-deoxyuridine

2′-Deoxyuridine ≥98.5%

Sigma-Aldrich

D5412

2′-Deoxyuridine

2′,3′-Dideoxycytidine ≥98% (HPLC)

Sigma-Aldrich

D5782

2′,3′-Dideoxycytidine

5-Iodo-2′-deoxyuridine ≥99% (HPLC)

Sigma-Aldrich

I7125

5-Iodo-2′-deoxyuridine

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder or crystals

assay

≥95% (HPLC)

assay

≥98.5%

assay

≥98% (HPLC)

assay

≥99% (HPLC)

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

solubility

water: 50 mg/mL, clear, colorless to yellow

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

1 N NH4OH: 50 mg/mL, clear to very slightly hazy, colorless to light yellow

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000498853
0000498853
0000383138
0000379790
0000324770

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E De Clercq et al.
The Journal of biological chemistry, 262(31), 14905-14911 (1987-11-05)
5-Ethyl-2'-deoxyuridine (EDU) is a potent and selective inhibitor of the replication of herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), which is currently being pursued for the topical treatment of HSV-1 and HSV-2 infections in humans. Using [4-14C]EDU as
Csilla Katona et al.
Magyar onkologia, 48(3), 243-251 (2004-11-03)
Pharmacologic modulation of 5-fluorouracil (5-FU) metabolism provides a possibility for the enhancement of its clinical efficacy. The purpose of the present work was to study the effect of 5-ethyl-2'-deoxyuridine (EUdR), a potent 5-FU modulator, on different molecular mechanisms, influenced by
A M Cheraghali et al.
Antiviral research, 25(3-4), 259-267 (1994-12-01)
Pharmacokinetic parameters for 5-ethyl-2'-deoxyuridine (EDU) were determined following intravenous (iv) and oral (po) dosing in male Balb-C mice and iv dosing in male Sprague-Dawley rats. The concentrations of EDU in blood after 100 mg/kg iv bolus injections into mice and
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SKUGTIN
E9386-1G04061826690840
E9386-250MG04061833048115

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