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D3676

10-Deacetylbaccatin III from Taxus baccata

≥95% (HPLC)

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Fórmula empírica (notación de Hill):
C29H36O10
Número CAS:
Peso molecular:
544.59
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
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biological source

Taxus baccata

Quality Segment

assay

≥95% (HPLC)

form

solid

mol wt

544.59 g/mol

color

white

solubility

methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@@H](O)C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C

InChI

1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1

InChI key

YWLXLRUDGLRYDR-ZHPRIASZSA-N

Application

10-Deacetylbaccatin III is used as a chemical intermediate in the preparation of the anti-cancer drug paclitaxel (Taxol). It is used to study the taxol biosynthetic pathway.

Biochem/physiol Actions

10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated.

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Este artículo
21871044583324622
description

≥95% (HPLC)

description

The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

suitable for fluorescence, 98.0-102.0% (HPLC)

description

The Eg5 Inhibitor III, Dimethylenastron, also referenced under CAS 863774-58-7, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Membrane applications.

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

mode of action

DNA synthesis | interferes

mode of action

-

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

98.0-102.0% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

powder

form

solid

solubility

methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)

solubility

DMSO: 10 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL

solubility

H2O: 50 mg/mL, clear, orange to red, DMSO: soluble, THF: soluble, ethanol: soluble, methanol: soluble

solubility

DMSO: 10 mg/mL, methanol: 5 mg/mL


pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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