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Key Documents

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A2380

Sigma-Aldrich

2-Aminopurine nitrate salt

≥99%

Sinónimos:

2-AP nitrate salt

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About This Item

Fórmula empírica (notación de Hill):
C5H5N5 · HNO3
Número de CAS:
51-16-1
Peso molecular:
198.14
MDL number:
MFCD00038989
UNSPSC Code:
41106305
PubChem Substance ID:
24890480
NACRES:
NA.51

biological source

synthetic

Quality Level

100

assay

≥99%

form

powder

solubility

water: 50 mg/mL, clear, faintly to light yellow

SMILES string

O[N+]([O-])=O.Nc1ncc2[nH]cnc2n1

InChI

1S/C5H5N5.HNO3/c6-5-7-1-3-4(10-5)9-2-8-3;2-1(3)4/h1-2H,(H3,6,7,8,9,10);(H,2,3,4)

InChI key

PGDNOZBGABWZLD-UHFFFAOYSA-N

Application

2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Junpei Teramachi et al.
Experimental cell research, 316(19), 3254-3262 (2010-08-24)
Double-stranded RNA-dependent protein kinase (PKR) plays a critical role in antiviral defence of the host cells. PKR is also involved in cell cycle progression, cell proliferation, cell differentiation, tumorigenesis, and apoptosis. We previously reported that PKR is required for differentiation
Renata M S Pereira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 617-626 (2009-10-09)
The evolution of Leishmania infection depends on the balance between microbicidal and suppressor macrophage functions. Double-stranded RNA (dsRNA)-activated protein kinase R (PKR), a classic antiviral protein, is able to regulate a number of signaling pathways and macrophage functions. We investigated
Michael E Lindquist et al.
Virology, 413(1), 103-110 (2011-03-08)
We performed experiments to determine the effect of PKR activation on respiratory syncytial virus (RSV) replication. We first determined that RSV infection activates PKR which induces the phosphorylation of eIF2α, resulting in the formation of host stress granules. We used
Yasumi Endoh et al.
Journal of immunology (Baltimore, Md. : 1950), 182(4), 2258-2268 (2009-02-10)
The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections. The S100A8-S100A9 complex facilitated viral replication in human CD4(+) T lymphocytes latently infected with HIV-1- and S100A8-induced HIV-1 transcriptional activity. Mechanisms inducing the S100 genes
Chen-Hsuan Wang et al.
Brain research bulletin, 79(3-4), 169-176 (2009-05-12)
Molecules involved in self-protection of neurons against glucose/oxygen/serum deprivation (GOSD) were investigated. Trypan blue dye exclusion assay, Western blotting, ELISA, cytokine antibody array and chemical blocking assay were applied in the study. Results showed that early induction (at 6h of
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