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14370

Sigma-Aldrich

Bilirrubina

purum, ≥95.0% (UV)

Sinónimos:

Bile pigment, Hemetoidin

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About This Item

Fórmula empírica (notación de Hill):
C33H36N4O6
Número de CAS:
635-65-4
Peso molecular:
584.66
Beilstein:
74376
Número CE:
211-239-7
Número MDL:
MFCD00005499
Código UNSPSC:
12352202
ID de la sustancia en PubChem:
57647150
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

purum

Ensayo

≥95.0% (UV)

Formulario

powder

residuo de ign.

≤0.5%

cadena SMILES

CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

Clave InChI

BPYKTIZUTYGOLE-IFADSCNNSA-N

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1 of 4

Este artículo
B4126201130891
Bilirrubina purum, ≥95.0% (UV)

14370

Bilirrubina

Bilirrubina ≥98% (EmM/453 = 60), powder

B4126

Bilirrubina

Bilirubin Principal pigment of bile and one of the major end products of hemoglobin decomposition.

2011

Bilirubin

Biliverdin hydrochloride ≥97.0% (TLC)

30891

Biliverdin hydrochloride

assay

≥95.0% (UV)

assay

≥98% (EmM/453 = 60)

assay

-

assay

≥97.0% (TLC)

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100

grade

purum

grade

-

grade

-

grade

-

ign. residue

≤0.5%

ign. residue

-

ign. residue

-

ign. residue

-

Descripción general

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.[1]

Aplicación

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I[2]. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.[3]

Acciones bioquímicas o fisiológicas

Más del 99 % de la bilirrubina total es transportada como un conjugado con la albúmina. Niveles anormalmente elevados de bilirrubina pueden causar un daño neurológico grave, pero niveles levemente elevados están vinculados a la protección frente al estrés oxidativo.
Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher.[1] This bile pigment has both antioxidant and toxic properties.[1] It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs).[4] It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases.[5][6] Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease.[7] It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.[7]

Nota de análisis

λmax. ∼453 nm, mol. absorption >56100 (chloroform)

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCL6435
BCCJ8864
BCCL1458
BCCH1649
BCCF8504

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Yen-Wen Wu et al.
Acta Cardiologica Sinica, 36(6), 649-659 (2020-11-26)
The rapid diagnosis of acute myocardial infarction (AMI) is a clinical and operational priority in emergency departments. Serial serum levels of cardiac biomarkers play a crucial role in the evaluation of patients presenting with acute chest pain, so that an
Stefan W Ryter et al.
American journal of respiratory cell and molecular biology, 36(2), 175-182 (2006-09-19)
Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentially relates
Kenichiro Yamashita et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 765-767 (2004-02-24)
Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now show that administration of biliverdin has a salutary effect in organ transplantation. A brief course
Robert Ollinger et al.
Circulation, 112(7), 1030-1039 (2005-08-10)
Bilirubin, a natural product of heme catabolism by heme oxygenases, was considered a toxic waste product until 1987, when its antioxidant potential was recognized. On the basis of observations that oxidative stress is a potent trigger in vascular proliferative responses
Bruno Hagenbuch et al.
Molecular aspects of medicine, 34(2-3), 396-412 (2013-03-20)
The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of
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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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