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M3761

Supelco

Metronidazole

analytical standard

Sinónimos:

2-Methyl-5-nitroimidazole-1-ethanol

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5 G
$87.70
25 G
$139.00
100 G
$372.00

$87.70

Disponible para envío el31 de marzo de 2025Detalles

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5 G
$87.70
25 G
$139.00
100 G
$372.00

About This Item

Fórmula empírica (notación de Hill):
C6H9N3O3
Número de CAS:
443-48-1
Peso molecular:
171.15
Beilstein:
611683
Número CE:
207-136-1
Número MDL:
MFCD00009750
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329817979
NACRES:
NA.24

$87.70

Disponible para envío el31 de marzo de 2025Detalles

Solicitar un pedido a granel

grado

analytical standard

Nivel de calidad

100

Formulario

crystalline

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

159-161 °C (lit.)

espectro de actividad antibiótica

Gram-negative bacteria
parasites

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Modo de acción

DNA synthesis | interferes

temp. de almacenamiento

2-8°C

cadena SMILES

CC1=NC=C([N+]([O-])=O)N1CCO

InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

Clave InChI

VAOCPAMSLUNLGC-UHFFFAOYSA-N

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Descripción general

Metronidazole is a nitroimidazole drug, used particularly against infections caused by anaerobic bacteria and protozoa in humans and domestic animals.

Aplicación

The analytical standard can be used as follows:
  • Cyclic voltametric determination of metronidazole at carbon paste electrode (CPE) in three different brands of metronidazole tablets
  • Simultaneous determination of metronidazole, diloxanide, spiramycin, and cliquinol in pharmaceutical dosage forms by reversed-phase high-performance liquid chromatography coupled to photodiode array detector (RP-HPLC-DAD)
  • Development of an electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nano-tubes (MWCNTs-COOH) nanocomposites for the determination of metronidazole
  • Liquid chromatography–ion trap mass spectrometry (LC-MS/MS based analysis of metronidazole in water, sediment, and fish tissue samples
  • Determination of metronidazole using an electrochemical sensor based on multi-walled carbon nanotubes (MWCNTs) and chitosan-nickel complexes (CTS-Ni) in tablets, human urine, and serum samples

Otras notas

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H340,H350,H373

Clasificaciones de peligro

Carc. 1B - Muta. 1B - STOT RE 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
WXBF3637V
WXBF2425V
WXBF2223V
WXBF1804V
WXBD6818V

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Alison L Huckenpahler et al.
Translational vision science & technology, 9(10), 18-18 (2020-09-29)
To observe and characterize cone degeneration and regeneration in a selective metronidazole-mediated ablation model of ultraviolet-sensitive (UV) cones in zebrafish using in vivo optical coherence tomography (OCT) imaging. Twenty-six sws1:nfsB-mCherry;sws2:eGFP zebrafish were imaged with OCT, treated with metronidazole to selectively
Sonja Löfmark et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50 Suppl 1, S16-S23 (2010-01-14)
Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy.
Linwei Li et al.
PLoS genetics, 15(2), e1007996-e1007996 (2019-02-15)
Pharyngeal pouches, a series of outpocketings that bud from the foregut endoderm, are essential to the formation of craniofacial skeleton as well as several important structures like parathyroid and thymus. However, whether pharyngeal pouch progenitors exist in the developing gut
Konstantinos Z Vardakas et al.
International journal of antimicrobial agents, 40(1), 1-8 (2012-03-09)
The objective of this review was to evaluate the frequency of treatment failure and recurrence of Clostridium difficile infection (CDI) following treatment with vancomycin or metronidazole in recently performed studies (last 10 years). Searches in PubMed and Scopus were performed
Samrah Masud et al.
Autophagy, 15(5), 796-812 (2019-01-25)
Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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