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G6529

Sigma-Aldrich

L-Glutatión reducido

≥98.0%, BioXtra

Sinónimos:

γ-L-glutamil-L-cisteinil-glicina, GSH

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About This Item

Fórmula lineal:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Número de CAS:
70-18-8
Peso molecular:
307.32
Beilstein/REAXYS Number:
1729812
EC Number:
200-725-4
MDL number:
MFCD00065939
UNSPSC Code:
12352209
PubChem Substance ID:
24895261
NACRES:
NA.26

product name

L-Glutatión reducido, BioXtra, ≥98.0%

product line

BioXtra

Quality Level

200

assay

≥98.0%

form

powder

impurities

≤0.02% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

color

white

mp

192-195 °C (dec.) (lit.)

solubility

H2O: 0.1 M, clear, colorless

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.02%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
Mg: ≤0.001%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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Amino Acid Sequence

γ-Glu-Cys-Gly

Application

Puede utilizarse a 5-10 mM para eluir la glutatión S-transferasa (GST) a partir de glutatión agarosa.

Biochem/physiol Actions

Antioxidante endógeno que desempeña un papel importante en la reducción de las especies de oxígeno reactivo formadas durante el metabolismo celular y el estallido respiratorio. La glutatión-S-transferasa cataliza la formación de tioéteres de glutatión con xenobióticos, leucotrienos y otras moléculas que tienen un centro electrofílico. El glutatión también forma enlaces de disulfuro con restos de cisteína de las proteínas. A través de estos mecanismos, puede tener el efecto paradójico de reducir la eficacia de los antineoplásicos.

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Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000376411
0000370708
0000369239
0000362245
0000362231

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Lisong Ma et al.
The New phytologist, 208(2), 507-518 (2015-05-15)
Plant-invading microbes betray their presence to a plant by exposure of antigenic molecules such as small, secreted proteins called 'effectors'. In Fusarium oxysporum f. sp. lycopersici (Fol) we identified a pair of effector gene candidates, AVR2-SIX5, whose expression is controlled
Hongwei Jiang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2281-2291 (2015-02-15)
Osteoclast differentiation and function are highly dependent on the assembly and turnover of actin filaments, but little is known about the roles of actin binding proteins in these processes. Adseverin (Ads), a member of the gelsolin superfamily of actin capping
Shinya Tsukiji et al.
Nature chemical biology, 5(5), 341-343 (2009-03-31)
Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living cells, tissues and mice but
Jamuna Risal Paudel et al.
Molecular plant-microbe interactions : MPMI, 28(5), 569-579 (2015-01-22)
One or more effectors in the labial saliva (LS) of generalist Noctuid caterpillars activate plant signaling pathways to modulate jasmonate (JA)-dependent defense responses; however, the exact mechanisms involved have yet to be elucidated. A potential candidate in this phytohormone interplay
Santiago Ramón-García et al.
Antimicrobial agents and chemotherapy, 53(9), 3675-3682 (2009-07-01)
Bacterial efflux pumps have traditionally been studied as low-level drug resistance determinants. Recent insights have suggested that efflux systems are often involved with fundamental cellular physiological processes, suggesting that drug extrusion may be a secondary function. In Mycobacterium tuberculosis, little
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