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Methyldibromoglutaronitrile

analytical standard

Sinónimos:

1,2-Dibromo-2,4-dicyanobutane, 1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile, 2-Bromo-2-(bromomethyl)glutaronitrile

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About This Item

Fórmula empírica (notación de Hill):
C6H6Br2N2
Número de CAS:
35691-65-7
Peso molecular:
265.93
EC Number:
252-681-0
MDL number:
MFCD00072483
UNSPSC Code:
85151701
PubChem Substance ID:
329754978
NACRES:
NA.24

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

51-55 °C

application(s)

environmental

format

neat

storage temp.

2-8°C

SMILES string

BrCC(Br)(CCC#N)C#N

InChI

1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2

InChI key

DHVLDKHFGIVEIP-UHFFFAOYSA-N

Categorías relacionadas

General description

Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.

Application

Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCK5706
BCCH7779
BCCG6594
BCCD2000
BCCB8384

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B C Carlsen et al.
The British journal of dermatology, 160(1), 103-106 (2008-11-19)
It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and
Marléne Isaksson et al.
Dermatitis : contact, atopic, occupational, drug, 18(4), 203-207 (2007-11-21)
Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s. This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a
Manuela Pellegrini et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1112-1116 (2011-08-30)
A simple and rapid gas chromatography (GC) method with mass spectrometry (MS) detection has been developed for the determination of methyldibromo glutaronitrile (MDBGN) in cosmetic products. The presence of this preservative in commercial cosmetic samples is prohibited since 2007 because
Methyldibromoglutaronitrile (Euxyl K400): A new and important sensitizer in the United States?
Jackson M.J, et al.
Journal of the American Academy of Dermatology, 38, 934-937 (1998)
L A Fischer et al.
The British journal of dermatology, 159(5), 1138-1143 (2008-09-18)
Methyldibromoglutaronitrile (MDBGN) is a preservative, which was approved for use in cosmetics in the mid-1980s. The incidence of allergy to MDBGN rose during the 1990s, but is now decreasing due to regulatory intervention. Experimental studies with other allergens have shown
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