492000-M

NOX Inhibitor III, VAS2870

The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.

• Sinónimos: NOX Inhibitor III, VAS2870, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
• Fórmula empírica (notación de Hill): C₁₈H₁₂N₆OS
• Número de CAS: 722456-31-7
• Peso molecular: 360.39
• Número MDL: MFCD03407188
• Código UNSPSC: 12352200

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: tan
• solubilidad: DMSO: 25 mg/mL
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC₅₀ = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (72% inhibition at 10 µM) ex vivo.

A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC₅₀ = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 µM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 µM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 µM).

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Wind, S., et al. 2010. Hypertension56, 490.
Lange, S., et al. 2009. Cardiovasc. Res.81, 159.
Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun.344, 200.
ten Freyhaus, H., et al. 2006. Cardiovasc. Res.71, 331.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable