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492002

NOX1 Inhibitor, ML171

Name: NOX1 Inhibitor, ML171
Brand: MM

The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1.

Sinónimos:

NOX1 Inhibitor, ML171, NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine

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Fórmula empírica (notación de Hill):

C₁₄H₁₁NOS

Número CAS:

6631-94-3

Peso molecular:

241.31

UNSPSC Code:

41121801

NACRES:

NA.77

MDL number:

MFCD00005017

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

Servicio técnico

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Propiedades

Quality Segment

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

dark yellow-orange

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S1c2c(cc(cc2)C(=O)C)Nc3c1cccc3

InChI

1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3

InChI key

JWGBOHJGWOPYCL-UHFFFAOYSA-N

Descripción

General description

A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC₅₀ = 0.129 µM, and 0.25 µM) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC₅₀ = 5 µM, 3 µM and 5 µM for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC₅₀ = 5.5 µM) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~ 100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC₅₀ >10 µM). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gianni, D., et al. 2010. ACS Chem. Biol.5, 981.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

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Número de artículo de comercio global

SKU	GTIN
492002-10MG	04055977273465