Saltar al contenido
MilliporeSigma

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Sinónimos:
5-HT2C, 5-HTR2C, HTR1C
Especie:
Human HTR2C (3358), Mouse Htr2c (15560), Rat Htr2c (25187), domestic cat HTR2C (101099620), naked mole-rat Htr2c (101726296), Horse HTR2C (100057852), cow HTR2C (538909), dog HTR2C (450240), chicken HTR2C (428707)
ID UniProtKB:
P28335, B1AMW4, Q5VUF8, Q9NP28
ID del gen:
  • Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
  • Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Referencia del producto
Descripción
Especie
D101
(±)-DOI hydrochloride, ≥98% (HPLC), solid,
Especie
human
D153
(R)(−)-DOI hydrochloride, ≥98% (HPLC), solid,
Especie
human
A1362
Agomelatine, ≥98% (HPLC),
Especie
human
M110
α-Methylserotonin maleate salt, ≥98% (HPLC),
Especie
human
N7261
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Especie
human

Small Molecule - Allosteric Modulator

Referencia del producto
Descripción
Especie
D9190
DCEBIO, ≥98% (HPLC), solid,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
142360
4-Benzylpiperidine, 99%,
Especie
rat
C-060
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human
300764
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, 98%,
Especie
rat
BP886
Cyclobenzaprine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Especie
human
C3200000
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB4501477
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
SAB4501478
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
SAB2500925
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
canine, human, mouse, rat
Aplicación
ELISA
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
M2525
Mianserin hydrochloride, ,
Especie
human
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Especie
human
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Especie
human
Z101
Zimelidine dihydrochloride, solid,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
T-030
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human
BP591
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
Especie
human
1673500
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Especie
human
BP590
Trazodone hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Especie
human
N5536
Nefazodone hydrochloride, ≥98% (HPLC), solid,
Especie
human

Small Molecule - Ligand

Referencia del producto
Descripción
Especie
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Especie
human

Small Molecule - Metabolite

Referencia del producto
Descripción
Especie
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Especie
human

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
M8046
Mifepristone, ≥98%,
Especie
human, mouse, rat
H1512
Haloperidol, powder,
Especie
human, rat
C6305
Clozapine, ,
Especie
human, rat

Small Molecule - Precursor

Referencia del producto
Descripción
Especie
H9772
5-Hydroxy-L-tryptophan, powder,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
HTS132M
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU120291
MISSION® esiRNA, targeting human HTR2C,
Especie
human