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Key Documents

WH0009152M1

Sigma-Aldrich

Monoclonal Anti-SLC6A5 antibody produced in mouse

clone 3B3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-GLYT2, Anti-NET1, Anti-solute carrier family 6 (neurotransmitter transporter, glycine), member 5

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3B3, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SLC6A5(9152)

General description

SLC6A5 (solute carrier 6A5) gene codes for the neuronal GlyT2 glycine transporter. GlyT2 is a member of the SLC6 solute carrier family of neurotransmitter sodium symporters.[1] This gene is located on human chromosome 11p15.[2]

Immunogen

SLC6A5 (NP_004202, 294 a.a. ~ 393 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
TLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIR

Biochem/physiol Actions

SLC6A5 (solute carrier 6A5) is a neurotransmitter transporter, which helps to maintain a high presynaptic pool of glycine at glycinergic synapses.[3] It participates in the removal and recycling of glycine from inhibitory synapses.[1] Mutations in GlyT2 gene result in presynaptic hyperekplexia[1] and startle disease.[3]

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia
Deng X, et al.
BMC Psychiatry (2008)
Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia
Arribas-Gonzalez E, et al.
The Journal of Biological Chemistry, 290(4), 2150-2165 (2015)
Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease
Carta E, et al.
The Journal of Biological Chemistry, 287(34), 28975-28985 (2012)

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