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Key Documents

WH0001264M1

Sigma-Aldrich

Monoclonal Anti-CNN1 antibody produced in mouse

clone 2F5-1H4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-SMCC, Anti-SmCalp, Anti-calponin 1, basic, smooth muscle

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2F5-1H4, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC022015

UniProt accession no.

P51911

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CNN1(1264)

Immunogen

CNN1 (AAH22015, 1 a.a. ~ 297 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA

Biochem/physiol Actions

Calponin 1 (CNN1) plays a key role in regulation of smooth muscle contraction in various physiological situations. Measurement of CNN1 level in maternal serum is considered to be a potent method for the short-term prediction of preterm birth in women with threatened preterm labor. CNN1 also acts as a cardiac and smooth muscle differentiation marker. In addition, it is also implicated in the actomyosin stabilization and cell motility repression.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor.
Cetin O
The Journal of Maternal-Fetal & Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 31, 216-222 (2018)
Identification of the Critical Site of Calponin 1 for Suppression of Ovarian Cancer Properties.
Yamane T
Anticancer Research, 35, 5993-5999 (2015)
Calponin1 inhibits dilated cardiomyopathy development in mice through the ?PKC pathway.
Lu D
International Journal of Cardiology, 173, 146-153 (2014)

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