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W2895

Sigma-Aldrich

WE-14 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

Chromogranin A fragment 324-337 trifluoroacetate salt, H-Trp-Ser-Lys-Met-Asp-Gln-Leu-Ala-Lys-Glu-Leu-Thr-Ala-Glu-OH trifluoroacetate salt, Human CgA 324-337 trifluoroacetate salt, Peptide WE-14 trifluoroacetate salt, WSRMDQLAKELTAE trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C72H116N18O24S · xC2HF3O2
CAS Number:
115136-18-0
Molecular Weight:
1649.86 (free base basis)
MDL number:
MFCD19686975
UNSPSC Code:
12352202
PubChem Substance ID:
329830540

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: >2 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C72H116N18O24S.C2HF3O2/c1-35(2)29-50(67(108)78-37(5)59(100)80-44(17-11-13-26-73)62(103)82-47(20-23-55(94)95)65(106)87-51(30-36(3)4)69(110)90-58(39(7)92)71(112)79-38(6)60(101)85-49(72(113)114)21-24-56(96)97)86-64(105)46(19-22-54(76)93)83-68(109)52(32-57(98)99)88-66(107)48(25-28-115-8)84-63(104)45(18-12-14-27-74)81-70(111)53(34-91)89-61(102)42(75)31-40-33-77-43-16-10-9-15-41(40)43;3-2(4,5)1(6)7/h9-10,15-16,33,35-39,42,44-53,58,77,91-92H,11-14,17-32,34,73-75H2,1-8H3,(H2,76,93)(H,78,108)(H,79,112)(H,80,100)(H,81,111)(H,82,103)(H,83,109)(H,84,104)(H,85,101)(H,86,105)(H,87,106)(H,88,107)(H,89,102)(H,90,110)(H,94,95)(H,96,97)(H,98,99)(H,113,114);(H,6,7)/t37-,38-,39+,42-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,58-;/m0./s1

InChI key

FZKRZHJMJIARGO-YVXXVKOOSA-N

Biochem/physiol Actions

WE-14 peptide is a highly conserved neuropeptide derived from Chromogranin A (Parathyroid Secretory Protein 1). It has been detected in vertebrate and invertebrate neurons and in vertebrate endocrine tissues, most notably in the adrenal, pituitary, and parathyroid glands, and has also been found in human and bovine gastro-entero-pancreatic tissues.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Colocalization of WE-14 immunostaining with the classical islet hormones in the porcine pancreas.
W J Curry et al.
Advances in experimental medicine and biology, 426, 139-144 (1997-01-01)
W J Curry et al.
Regulatory peptides, 113(1-3), 41-47 (2003-04-11)
WE-14 is derived from the cell-specific posttranslational processing of chromogranin A (CgA) in subpopulations of neuroendocrine cells and neurons. Region- and site-specific chromogranin A, pancreastatin and WE-14 antisera were employed to study the generation of WE-14 in porcine ocular tissues.
Chromogranin A and its derived peptides in the rat and porcine gastro-entero-pancreatic system. Expression, localization, and characterization.
W J Curry et al.
Advances in experimental medicine and biology, 482, 205-213 (2001-02-24)
P Norlén et al.
Regulatory peptides, 70(2-3), 121-133 (1997-06-18)
The ECL cells constitute the predominant endocrine cell population in the mucosa of the acid-secreting part of the stomach (fundus). They are rich in chromogranin A (CGA), histamine and histidine decarboxylase (HDC). They secrete CGA-derived peptides and histamine in response
S C Barkatullah et al.
Histochemistry and cell biology, 116(3), 255-262 (2001-10-31)
Immunohistochemical investigation of the post-translational processing of chromogranin A (CgA) to generate WE-14 in the sympathoadrenal cell lineage of the developing porcine fetus (F) detected intense CgA and weak WE-14 immunoreactivity in migrating neuroblast cells of the diffuse sympathetic ganglia
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