T9177
Tyrphostin AG 126
≥90%
Synonym(s):
(3-Hydroxy-4-nitrobenzylidene)malononitrile
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About This Item
Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
Molecular Weight:
215.17
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥90%
storage temp.
−20°C
SMILES string
Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N
Gene Information
human ... TNF(7124)
Application
Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.
Biochem/physiol Actions
Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk_germany
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Hua Yuan et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H470-H479 (2008-12-23)
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial depression that is a common feature of endotoxemia in patients. In this setting the myocardial dysfunction appears to be due
M G Rittig et al.
Cellular microbiology, 5(12), 887-899 (2003-12-04)
Following reports that a VacA+cag+ toxigenic but not a VacA-cag- non-toxigenic Helicobacter pylori strain induced homotypic phagosome fusion in murine macrophages, we addressed that phenomenon in human cells. Mononuclear phagocytes and epitheloid cells were challenged with H. pylori strains of
Klemens Angstwurm et al.
Infection and immunity, 72(6), 3294-3298 (2004-05-25)
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components contributes to this devastating outcome. In vitro studies have
Jacob George et al.
Experimental and molecular pathology, 76(3), 234-241 (2004-05-06)
Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder; the involvement of TNF-alpha in this disorder has been demonstrated. EAM represents a model for human autoimmune myocarditis, a condition for which no optimal treatment is currently available. Tyrphostins AG-126
Srinivasan Balachandra et al.
Surgery, 138(5), 913-923 (2005-11-18)
The effects of the tyrosine kinase inhibitors, tyrphostin AG126 and AG556 in a murine model of acute pancreatitis are investigated. Intraperitoneal injection of cerulein in mice resulted in a severe, acute pancreatitis, which was characterized by edema, neutrophil infiltration, tissue
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